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| Continued
from page 6
in addition, to its oncolytic properties, is able to stimulate
specific and lasting anti-tumor immunity in mice."
The
hypothesis of Dr. Curry's group is that pulsing immature
dendritic cells with G207-infected tumors cells is a potent
activating stimulus for antigen presentation and generation
of antitumor immunity, to be demonstrated by vaccine treatment
in mice bearing subcutaneous and intracranial Neuro2a tumors.
Also, the group proposes that increasing the number of
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dendritic
cells in tumors, either by coinjection of ex vivo generated
cells, or by systemic mobilization from the bone marrow by
Flt3L, a growth factor, increases antitumor immunity in the
context of oncolytic virus infection. "I became very
interested in the antitumor immune response that is provoked
by oncolytic herpes virus." said Dr. Curry. "Not
only does the virus kill the tumor cells themselves, but also
it kicks off an immune response against the tumors. I'm looking
at ways of, one, understanding that, and two augmenting the
effect."
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Dr.
Curry is excited and
pleased
to have won this award, especially in the context of his position
at MGH. He said:
"Here,
more than any other place, I imagine, I have the opportunity
to focus on building an academic neurosurgery career with
great mentorship, and also with excellent opportunities
for clinical and basic research. I have great role models…the
whole environment fosters the development of young investigator-clinicians.
In particular, my research is very generously supported
by my department and by Dr. Martuza
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| Neuroscience
Series centers on functional , stereotactic |
| The
2004-5 Neuroscience Series expanded to include the Massachusetts
Eye and Ear Departments of Otolaryngology and Opthamology
in addition to the MGH departments of Neurosurgery, Neurology
and Psychiatry.
The
2004-5 series was organized by Dr. Emad N. Eskandar. Speakers
in the Neurosurgery section of the series were Learning
and Memory Mechanisms of the Basal Ganglia, Ann Martin Graybiel,
PhD Walter A Rosenblith Professor of Neuroscience, Department
of Brain and Cognitive Sciences,
|
Massachusetts
Institute of Technology in the Department of Brain and Cognitive
Sciences
Computing
with Neural Ensembles, Miguel AL Nicolelis, MD, PhD, Professor
in the Departments of Neurobiology, Biomedical Engineering
and Psychological and Brain Science Co-Director, Center
for Neuroengineering at Duke University Medical Center in
Durham, North Carolina.
Functional
Inhibition of Deep Brain Structures by High Frequency Stimulation:
Application to Movement Disorders and other Nervous
|
Diseases, and Mechanism of Action, Professor Alim Louis Benabid,
MD, PhD, Professor at Grenoble University, Neurosurgery and
Biophysics, Director of the research laboratory INSERM unit
318, (Preclinical Neurosciences), and has been Head of the
Neurosurgery Department at the University Hospital of Grenoble,
Professor of Biophysics (exceptional class) at the Joseph
Fourier University ;Coordinator Claudio Munari center for
surgery of epilepsy and movement disorders, at hospital Ni
Guardia, Milan. |
| Dr.
Jeffrey Macklis receives Senator Javits Award |
|
Continued
from page 6
somatosensory
cortex, which receives tactile information from the body,
and the motor cortex, which sends out motor control information
to the body. Macklis' findings may lead to the development
of cell replacement therapies to treat brain disorders and
spinal cord injury.
"This
award and extended funding will allow us to continue to
take risks in new
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directions,
especially toward the directed differentiation and functional
integration of replacement neurons derived from adult neural
precursors, also called 'adult neural stem cells,'" Macklis
said.
The
$2.8 million award, created in 1983, honors the late U.S.
Senator Jacob Javits, who suffered from amyotrophic lateral
sclerosis and was an advocate for research on neurological
disorders.
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